Structure−Activity Studies on Antiproliferative Factor (APF) Glycooctapeptide Derivatives

Interstitial cystitis antiproliferative factor (APF) as a cell-cycle modulator

BACKGROUND Interstitial cystitis (IC) is a chronic bladder disorder of unknown etiology. Antiproliferative factor (APF), a peptide found in the urine of IC patients, has previously been shown to decrease incorporation of thymidine by normal bladder epithelial cells. This study was performed to determine the effect of APF on the cell cycle of bladder epithelial cells so as to better understand i...

Studies on the Antiproliferative Action of Interferon

STUDIES ON THE ANTIPROLIFERATIVE ACTION OF INTERFERON. Effect on proteins synthesized in the Gl and S phase of the cell cycle in 2 anchorage-dependent cell lines. Dan Lundblad, Unit of Applied Cell and Molecular Biology, University of Umeå, S-901 87 Umeå. Interferons (IFNs) are a class of structurally related proteins first discovered to be produced by virus-infected cells. By now, several othe...

Studies on nicotinamide derivatives.

Antiproliferative activity of new benzimidazole derivatives.

A series of new benzimidazole derivatives were synthesized and tested in vitro for possible anticancer activity. Their effect of proliferation into selected tumor cell lines at normoxia and hypoxia conditions was determined by WST-1 test. Additionally, apoptosis test (caspase 3/7 assay) was used to check the mode caused by the agents of cell death. Four of the examined compounds (7, 8, 13, 11) ...

Lipophilicity Studies on Thiosemicarbazide Derivatives.

The lipophilicity of two series of thiosemicarbazide derivatives was assessed by the RP-HPLC method with the RP-18 chromatographic column and the methanol-water mixture as the mobile phase. Distribution coefficients logPHPLC were compared to calculated values generated by commonly used AClogP software and quantum chemical calculations. The reliability of the predictions was evaluated using the ...